Ticasino Medication

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Generic Name:dofetilide (doe FET i lide)
Brand Name:Tikosyn

What is Tikosyn?

Tikosyn is a heart rhythm medicine, also called an antiarrhythmic.

Tikosyn is used to help keep the heart beating normally in people with certain heart rhythm disorders of the atrium (the upper chambers of the heart that allow blood to flow into the heart). This medicine is used in people with atrial fibrillation or atrial flutter.

Tikosyn may also be used for purposes not listed in this medication guide.

Medication

Important Information

You should not take Tikosyn if you have severe kidney disease or a history of Long QT syndrome.

Serious drug interactions can occur when certain medicines are used together with Tikosyn. Tell each of your healthcare providers about all medicines you use now, and any medicine you start or stop using.

You will need to spend at least 3 days in a hospital setting when you first start taking Tikosyn. This is so your heart rhythm and kidney function can be monitored in case the medicine causes serious side effects.

Before taking this medicine

You should not take Tikosyn if you are allergic to it, or if you have:

  • severe kidney disease (or if you are on dialysis); or

  • a history of Long QT syndrome.

Some medicines can cause unwanted or dangerous effects when used with Tikosyn, and should not be used at the same time. Your doctor may need to change your treatment plan if you use any of the following drugs:

  • cimetidine;

  • dolutegravir;

  • ketoconazole;

  • megestrol;

  • prochlorperazine;

  • trimethoprim (Proloprim, Trimpex, Bactrim, Septra);

  • verapamil; or

  • a diuretic (water pill) that contains hydrochlorothiazide (HCTZ), such as Accuretic, Aldactazide, Atacand HCT, Benicar HCT, Diovan HCT, Dyazide, Exforge HCT, Hyzaar, Lopressor HCT, Maxzide, Micardis HCT, Monopril HCT, Prinzide, Tekturna HCT, Vaseretic, and others.

To make sure Tikosyn is safe for you, tell your doctor if you have:

  • heart disease, high blood pressure;

  • liver or kidney disease;

  • depression, mental illness;

  • asthma or allergies;

  • any active infection;

  • skin problems; or

  • an electrolyte imbalance (such as low levels of potassium or magnesium in your blood).

It is not known whether Tikosyn will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine.

It is not known whether dofetilide passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are using dofetilide.

How should I take Tikosyn?

Tikosyn is available only from a hospital or specialty pharmacy.

You will need to spend at least 3 days in a hospital setting when you first start taking Tikosyn. This is so your heart rhythm and kidney function can be monitored in case the medicine causes serious side effects.

Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

You may take Tikosyn with or without food.

You should not skip doses or stop using Tikosyn suddenly. Stopping suddenly may make your condition worse. Follow your doctor's instructions about tapering your dose.

Tell your doctor if you have a prolonged illness that causes severe diarrhea, vomiting, or heavy sweating. These conditions can cause an electrolyte imbalance, making it dangerous for you to use Tikosyn.

Your blood pressure will need to be checked often. Your kidney function may also need to be checked with frequent blood tests.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Skip the missed dose and take your next dose at the usual time to stay on schedule. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Tikosyn?

Grapefruit and grapefruit juice may interact with Tikosyn and lead to unwanted side effects. Discuss the use of grapefruit products with your doctor.

Tikosyn side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • headache with chest pain and severe dizziness, fainting, fast or pounding heartbeats;

  • loss of appetite, vomiting or severe diarrhea; or

  • low magnesium or potassium--confusion, uneven heart rate, increased thirst or urination, sweating, jerking muscle movements, leg discomfort, muscle weakness or limp feeling.

Common side effects may include:

  • mild headache;

  • mild dizziness; or

  • cold symptoms such as stuffy nose, sneezing, sore throat.

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This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Tikosyn?

Other drugs may interact with dofetilide, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Copyright 1996-2021 Cerner Multum, Inc. Version: 4.01.

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Ticasino medication

Generic Name:Dofetilide (doe FET il ide)
Brand Name: Tikosyn

Medically reviewed by Drugs.com. Last updated on June 22, 2020.

Warning

  • There is a risk that Tikosyn (dofetilide) may cause another type of abnormal heartbeat, which may be deadly. You will have to start and restart this drug in a setting where your heart will be watched nonstop. Talk with your doctor.

Uses of Tikosyn:

  • It is used to keep a normal heartbeat in people who have a certain type of abnormal heartbeat (atrial fibrillation or atrial flutter).
  • It may be used to turn atrial fibrillation or flutter into a normal heartbeat.

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What do I need to tell my doctor BEFORE I take Tikosyn?

  • If you have an allergy to dofetilide or any other part of Tikosyn (dofetilide).
  • If you are allergic to Tikosyn (dofetilide); any part of Tikosyn (dofetilide); or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
  • If you have kidney disease.
  • If you have any of these health problems: Long QT on ECG, low magnesium levels, or low potassium levels.
  • If you are taking any drugs used for a heartbeat that is not normal.
  • If you are taking any of these drugs: Cimetidine, dolutegravir, hydrochlorothiazide, itraconazole, ketoconazole, megestrol, prochlorperazine, trimethoprim, or verapamil.
  • If you are taking any drugs that can cause a certain type of heartbeat that is not normal (prolonged QT interval). There are many drugs that can do this. Ask your doctor or pharmacist if you are not sure.
  • If you are breast-feeding. Do not breast-feed while you take Tikosyn (dofetilide).

This is not a list of all drugs or health problems that interact with Tikosyn (dofetilide).

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Tikosyn (dofetilide) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Tikosyn?

  • Tell all of your health care providers that you take Tikosyn (dofetilide). This includes your doctors, nurses, pharmacists, and dentists.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • You will need an ECG before starting Tikosyn (dofetilide) and during treatment. Talk with your doctor.
  • Tell your doctor if you have too much sweat, fluid loss, throwing up, diarrhea, not hungry, or more thirst.
  • If you drink grapefruit juice or eat grapefruit often, talk with your doctor.
  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using Tikosyn (dofetilide) while you are pregnant.

How is this medicine (Tikosyn) best taken?

Use Tikosyn (dofetilide) as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • Take with or without food.
  • It is important that you do not miss or skip a dose of Tikosyn (dofetilide) during treatment.
  • Keep taking Tikosyn (dofetilide) as you have been told by your doctor or other health care provider, even if you feel well.

What do I do if I miss a dose?

  • Never make up a missed dose. Skip the missed dose and go back to your normal time.
  • Do not take 2 doses at the same time or extra doses.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Chest pain or pressure.
  • Dizziness.
  • Shortness of breath.
  • A type of abnormal heartbeat (prolonged QT interval) has happened with Tikosyn (dofetilide). Sometimes, this has led to another type of unsafe abnormal heartbeat (torsades de pointes). Call your doctor right away if you have a fast or abnormal heartbeat, or if you pass out.

What are some other side effects of Tikosyn?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Headache.
  • Upset stomach.
  • Signs of a common cold.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.

Tikosyn side effects(more detail)

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Tikosyn?

  • Store at room temperature.
  • Keep lid tightly closed.
  • Store in a dry place. Do not store in a bathroom.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Consumer information use

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • This medicine comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time Tikosyn (dofetilide) is refilled. If you have any questions about Tikosyn (dofetilide), please talk with the doctor, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
Ticasino MedicationMedication

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

More about Tikosyn (dofetilide)

Consumer resources

Professional resources

Related treatment guides